以下是引用amei在2007-7-11 8:33:07的发言：强烈关注，什么时候能临床呢？另外不知道所说的四氢大麻酚的作用机理是不是和易瑞沙的作用机理有相似之处，易瑞沙耐药后是否可以作为一种选择呢？另外他是否可以通过血脑屏障，对脑转移有没有治疗作用呢？期待知道更多信息的病友能够接着报道。 1)我从网上查到，大麻酚是受 严格控制的药物(与毒品有关)，所以 应是早已用于临床了，可能和吗啡类药物差不多。？？？
2)应该可用于易瑞沙耐药后的选择，人们发现大麻酚可用于治疗肺癌起因于，科学家首先发现大麻焦油中，导致肺癌的物质比烟中多50%，因此美国 FDA想发出大麻导致肺癌的警告，搞了个调查统计，但结果大出意外，长期抽大麻的人没有一人得肺癌。结果，人们反过来研究大麻，发现大麻是抗癌的。
现在只是不知用量应是多少。
下面附录华盛顿邮报关于那次调查统计的报道：
Study Finds No Cancer-Marijuana Connection
By Marc Kaufman
Washington Post Staff Writer
Friday, May 26, 2006; A03
The
largest study of its kind has unexpectedly concluded that smoking
marijuana, even regularly and heavily, does not lead to lung cancer. The
new findings "were against our expectations," said Donald Tashkin of
the University of California at Los Angeles, a pulmonologist who has
studied marijuana for 30 years. "We hypothesized that there would
be a positive association between marijuana use and lung cancer, and
that the association would be more positive with heavier use," he said.
"What we found instead was no association at all, and even a suggestion
of some protective effect." Federal health and drug enforcement
officials have widely used Tashkin's previous work on marijuana to make
the case that the drug is dangerous. Tashkin said that while he still
believes marijuana is potentially harmful, its cancer-causing effects
appear to be of less concern than previously thought. Earlier
work established that marijuana does contain cancer-causing chemicals
as potentially harmful as those in tobacco, he said. However, marijuana
also contains the chemical THC, which he said may kill aging cells and
keep them from becoming cancerous. Tashkin's study, funded by the
National Institutes of Health's National Institute on Drug Abuse,
involved 1,200 people in Los Angeles who had lung, neck or head cancer
and an additional 1,040 people without cancer matched by age, sex and
neighborhood. They were all asked about their lifetime use of
marijuana, tobacco and alcohol. The heaviest marijuana smokers had
lighted up more than 22,000 times, while moderately heavy usage was
defined as smoking 11,000 to 22,000 marijuana cigarettes. Tashkin found
that even the very heavy marijuana smokers showed no increased
incidence of the three cancers studied. "This is the largest
case-control study ever done, and everyone had to fill out a very
extensive questionnaire about marijuana use," he said. "Bias can creep
into any research, but we controlled for as many confounding factors as
we could, and so I believe these results have real meaning." Tashkin's
group at the David Geffen School of Medicine at UCLA had hypothesized
that marijuana would raise the risk of cancer on the basis of earlier
small human studies, lab studies of animals, and the fact that
marijuana users inhale more deeply and generally hold smoke in their
lungs longer than tobacco smokers -- exposing them to the dangerous
chemicals for a longer time. In addition, Tashkin said, previous
studies found that marijuana tar has 50 percent higher concentrations
of chemicals linked to cancer than tobacco cigarette tar. While
no association between marijuana smoking and cancer was found, the
study findings, presented to the American Thoracic Society
International Conference this week, did find a 20-fold increase in lung
cancer among people who smoked two or more packs of cigarettes a day. The
study was limited to people younger than 60 because those older than
that were generally not exposed to marijuana in their youth, when it is
most often tried.
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发表于 2007-7-11 09:15:47
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