求：特罗凯耐药后的治疗方案！！（妈妈2007年12月4日病逝！）

东方

jimmy,小路，你们好：看来你们的用药和抗药后处理方式和我妈妈的都差不多，我妈妈在易瑞沙抗药后做了2期力比泰（2个月），无效后改服特罗凯，坚持了3个月就开始。看来，“再次抗药时间好像和停药时间成正比”这一说法还是有支持的。

小路，你现在用的什么治疗方案？我打算给我妈试DCA，已托人从美国定购，估计这周会到货。

小路

东方，你好! 我现在用的是“易”+“反应停”。

东方

小路，我妈妈的主治医生对不赞成我用“易”+“反应停”，这个月把特罗凯服完月底做个CT做个详细的评估，我也准备等DCA到了后一起服用。

你何时开始服用“易”+“反应停”的，现在情况如何？

小路

6月6日开始的，至今一个月,昨天ct片已拿到显示：稳定。

东方

稳定就是胜利，加油！

我也在为妈妈服用DCA做准备工作，希望DCA这周能准时寄到。

jimmy112199

东方，小路：最新资料：吸大麻可以显著减少肺癌的扩散。下面是哈佛大学医学院今年4月报道的结果。

Source:      American Association for Cancer Research
Date:         April 17, 2007
来源： 美国癌症研究协会， 2007/4/17


Marijuana Cuts Lung Cancer Tumor Growth In Half, Study Shows
研究显示： 大麻减少肺癌肿瘤增长一半

Science Daily — The active ingredient in marijuana cuts tumor growth in common lung cancer in half and significantly reduces the ability of the cancer to spread, say researchers at Harvard University who tested the chemical in both lab and mouse studies.
每日科学--哈佛大学的科研人员，在实验室和老鼠身上测试了大麻的化学成分后说，大麻活跃成分将通常肺癌肿瘤增长消减到一半，显著减少了癌(细胞)的扩散能力

They say this is the first set of experiments to show that the compound, Delta-tetrahydrocannabinol (THC), inhibits EGF-induced growth and migration in epidermal growth factor receptor (EGFR) expressing non-small cell lung cancer cell lines. Lung cancers that over-express EGFR are usually highly aggressive and resistant to chemotherapy.

THC that targets cannabinoid receptors CB1 and CB2 is similar in function to endocannabinoids, which are cannabinoids that are naturally produced in the body and activate these receptors. The researchers suggest that THC or other designer agents that activate these receptors might be used in a targeted fashion to treat lung cancer.

"The beauty of this study is that we are showing that a substance of abuse, if used prudently, may offer a new road to therapy against lung cancer," said Anju Preet, Ph.D., a researcher in the Division of Experimental Medicine.

Acting through cannabinoid receptors CB1 and CB2, endocannabinoids (as well as THC) are thought to play a role in variety of biological functions, including pain and anxiety control, and inflammation. Although a medical derivative of THC, known as Marinol, has been approved for use as an appetite stimulant for cancer patients, and a small number of U.S. states allow use of medical marijuana to treat the same side effect, few studies have shown that THC might have anti-tumor activity, Preet says. The only clinical trial testing THC as a treatment against cancer growth was a recently completed British pilot study in human glioblastoma.

In the present study, the researchers first demonstrated that two different lung cancer cell lines as well as patient lung tumor samples express CB1 and CB2, and that non-toxic doses of THC inhibited growth and spread in the cell lines. "When the cells are pretreated with THC, they have less EGFR stimulated invasion as measured by various in-vitro assays," Preet said.

Then, for three weeks, researchers injected standard doses of THC into mice that had been implanted with human lung cancer cells, and found that tumors were reduced in size and weight by about 50 percent in treated animals compared to a control group. There was also about a 60 percent reduction in cancer lesions on the lungs in these mice as well as a significant reduction in protein markers associated with cancer progression, Preet says.

Although the researchers do not know why THC inhibits tumor growth, they say the substance could be activating molecules that arrest the cell cycle. They speculate that THC may also interfere with angiogenesis and vascularization, which promotes cancer growth.

Preet says much work is needed to clarify the pathway by which THC functions, and cautions that some animal studies have shown that THC can stimulate some cancers. "THC offers some promise, but we have a long way to go before we know what its potential is," she said.

Note: This story has been adapted from a news release issued by American Association for Cancer Research.

[此贴子已经被作者于2007-7-11 5:45:11编辑过]

jimmy112199

这是第2篇报道，这里还还有其他医学院的试验。

Marijuana Compound May Fight Lung Cancer

From:

Apr 17, 2007

While smoking marijuana is never good for the lungs, the active ingredient in pot may help fight lung cancer, new research shows.

Harvard University researchers have found that, in both laboratory and mouse studies, delta-tetrahydrocannabinol (THC) cuts tumor growth in half in common lung cancer while impeding the cancer’s ability to spread.

The compound “seems to have a suppressive effect on certain lines of cancer cells,” explained Dr. Len Horovitz, a pulmonary specialist at Lenox Hill Hospital in New York City.

According to the researchers, THC fights lung cancer by curbing epidermal growth factor (EGF), a molecule that promotes the growth and spread of particularly aggressive non-small cell lung cancers. “It seems to go to (EGF) receptor sites on cells and inhibit growth,” said Horovitz, who was not involved in the study.

The findings are preliminary, however, and other outside experts urged caution.

“It’s an interesting laboratory study (but) you have to have enough additional animal studies to make sure the effect is reproducible and to make sure that there are no overt toxic effects,” said Dr. Norman Edelman, chief medical officer of the American Lung Association. “It’s a little more than tantalizing because it’s a compound that we know has been in humans and has not caused major problems.”

The findings were to be presented this week at the annual meeting of the American Association for Cancer Research (AACR) in Los Angeles.

Lung cancer is the number one cancer killer in the world. Lung tumors that over-produce the EGF receptor tend to be extra-aggressive and don’t respond well to chemotherapy.

THC is the main active ingredient of Cannabis sativa –marijuana. It has been shown to inhibit tumor growth in cancer, but specific information on its action against lung cancer has so far been limited.

In the new study, the researchers first showed that two different lung cancer lines, as well as samples from patient lung tumors, produced the cannabinoid receptors CB1 and CB2.

Endocannabinoids — cannabinoids produced naturally in the body — are thought to have an effect on pain, anxiety and inflammation when they bind to cannabinoid receptors.

Next, the researchers injected standard doses of THC into mice implanted with human lung cancer cells. After three weeks of treatment, tumors shrank by about 50 percent in animals treated with THC, compared to those in an untreated control group, the researchers reported.

The findings may shed light on a question that has been puzzling Horovitz: Why hasn’t there been a spike in lung cancer in the generation that smoked a lot of marijuana in the 1960s.

“I find it fascinating, wondering if the reasons we’re not seeing this spike is that THC inhibits lung cancer cells,” he said. “It would be very ironic, although you certainly wouldn’t tell somebody who smoked cigarettes to add marijuana.”

A second set of findings presented at AACR suggested that a viral-based gene therapy could target both primary and distant tumors, while ignoring healthy cells.

When injected into 15 mice with prostate cancer, this “smart bomb” therapy eliminated all signs of cancer — effectively curing the rodents. Researchers at Columbia University, in New York City, said the therapy also worked in animals with breast cancer and melanomas.

And in a third hopeful trial reported at the meeting, German researchers at University Children’s Hospital, in Ulm, said they’ve used measles viruses to treat brain tumors. In mouse experiments, the virus attached to the tumor from the inside out, the team said.

amei

强烈关注，什么时候能临床呢？另外不知道所说的四氢大麻酚的作用机理是不是和易瑞沙的作用机理有相似之处，易瑞沙耐药后是否可以作为一种选择呢？另外他是否可以通过血脑屏障，对脑转移有没有治疗作用呢？期待知道更多信息的病友能够接着报道。