It is noteworthy to mention that the incidence of interstitial pneumonitis is much higher if paclitaxel is given concurrently with radiation (47% of patients) [49Go] or with other agents having the potential to cause lung toxicity, including gemcitabine (33% of patients) [50Go]. Other rare side-effects are diffuse alveolar damage and lung fibrosis. The former has been described in two patients treated with paclitaxel and gemcitabine [51Go] and the latter in one patient treated with paclitaxel and carboplatin