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发表于 2009-8-10 21:12:16
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来自: 英国
CEA监测
http://books.google.co.uk/books? ... %20rise&f=false
这上面有提到用CEA监测大肠癌治疗的效果,CEA持续升高,说明疗效减低。有的时候CEA持续升高8个月后才有临床和影像学上的表现(具体内容在其它检测那一章)。
这里也有提到监测CEA的可取性,不知道为什么上次肿瘤医院的医生竟然说不要管它。
Abstract
Through persistent clinical research efforts, the CEA test has developed into a useful although complex disease monitor for colorectal cancer. Although improved or prolonged survival from its use has not been demonstrated, CEA monitoring may allow more knowledgeable patient management. Several reports indicate that postoperative serial CEA assays may identify patients with early recurrence, especially when assays are done frequently. Patients with elevated pretreatment CEA levels usually showed progressively rising titers before other objective evidence of recurrence was apparent. A progressively rising CEA titer correlated well with recurrent cancer, but a normal CEA could not be used as proof of its absence. Persistently elevated CEA titers post-treatment were caused either by persistent disease or by nontumor-related factors. The CEA assay was not a substitute for clinical follow-up but was an adjunct in the diagnosis of early recurrence.
Patients with elevated CEA levels caused by localized disease treated by radiation therapy demonstrated a marked fall in serial CEA levels if all CEA-producing tumor was localized within the radiation portal. The use of pretreatment CEA values plus the pattern of CEA response to irradiation may help in the selection of fulguration versus abdominoperineal resection as primary treatment for rectal cancer. Persistently low serial CEA titers after irradiation therapy correlated with disease control.
The use of frequent serial CEA assays in patients treated with chemotherapy compared well with other parameters as a monitor of disease progression or regression. When used with other clinical parameters, serial CEA trends appeared to be a useful adjunct in assessing the effectiveness of chemotherapy. A fall in circulating CEA or the stabilization of a rising titer after starting chemotherapy usually indicated an effective regimen, whereas a rising CEA titer may signal the need to initiate or to change chemotherapy.
Abstract
Monthly serial postoperative CEA determinations, three-monthly system review plus physical examination, and a battery of six-monthly laboratory and radio-logic tests were compared in order to evaluate each in detection of recurrent colorectal cancer. Twelve of the 33 patients studied prospectively developed recurrent disease. In this study CEA was found not to be a substitute for careful clinical follow-up, but if used in a serial manner it was a useful adjunct for detection of early recurrent cancer, especially intra-hepatic and retroperitoneal disease recurring in patients with elevated pretreatment CEA levels. The other laboratory and radiologic tests employed were often useful to confirm progressing disease, but they did not reveal any first evidence of recurrent disease.
Tumor Markers CEA, CA19-9 and CA125 in Monitoring of Response to Systemic Chemotherapy in Patients with Advanced Gastric Cancer
http://jjco.oxfordjournals.org/cgi/content/full/29/11/550
CARCINOEMBRYONIC ANTIGEN (CEA) MONITORING IN THE MANAGEMENT OF RADIOTHERAPEUTIC
AND CHEMOTHERAPEUTIC PATIENTS*
www.ajronline.org/cgi/reprint/124/4/630.pdf
http://books.google.co.uk/books? ... %20rise&f=false
[ 本帖最后由 共创奇迹 于 2009-8-10 21:18 编辑 ] |
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