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发表于 2007-6-8 11:12:33
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来自: 美国
<p class="MsoNormal"><span style="font-family: "MS Mincho";">Re-treatment with gefitinib in advanced lung adenocarcinoma
patients: a<span>  </span>retrospective analysis <op></op></span></p>
<p class="MsoNormal"><span style="font-family: "MS Mincho";">Takashi Kasai<span>  </span>1<span>  </span>, Hiroshi Soda<span>  </span>2<span>  </span>,
Hiroshi Takatani<span>  </span>3<span>  </span>, Minoru Fukuda<span>  </span>4<span>  </span>,
Reiji Nakano<span>  </span>3<span>  </span>,<span> 
</span>Akitoshi Kinoshita<span>  </span>3<span>  </span>, Masaaki Fukuda<span>  </span>3<span>  </span>,
Seiji Nagashima<span>  </span>3<span>  </span>, Yoichi Nakamura<span>  </span>2<span>  </span>,
Yoshifumi Soejima<span>  </span>3<span>  </span>,<span> 
</span>Mikio Oka<span>  </span>4<span>  </span>, Shigeru Kohno<span>  </span>2<span>  </span><op></op></span></p>
<p class="MsoNormal"><span style="font-family: "MS Mincho";">1<span>  </span></span><st1place><st1placename><span style="font-family: "MS Mincho";">Isahaya</span></st1placename><span style="font-family: "MS Mincho";">
</span><st1placename><span style="font-family: "MS Mincho";">General</span></st1placename><span style="font-family: "MS Mincho";">
</span><st1placetype><span style="font-family: "MS Mincho";">Hospital</span></st1placetype></st1place><span style="font-family: "MS Mincho";">, </span><st1place><st1city><span style="font-family: "MS Mincho";">Nagasaki</span></st1city><span style="font-family: "MS Mincho";">, </span><st1country-region><span style="font-family: "MS Mincho";">Japan</span></st1country-region></st1place><span style="font-family: "MS Mincho";"><span>  </span><op></op></span></p>
<p class="MsoNormal"><span style="font-family: "MS Mincho";">2<span>  </span></span><st1place><st1placename><span style="font-family: "MS Mincho";">Nagasaki</span></st1placename><span style="font-family: "MS Mincho";">
</span><st1placetype><span style="font-family: "MS Mincho";">University</span></st1placetype><span style="font-family: "MS Mincho";">
</span><st1placetype><span style="font-family: "MS Mincho";">School</span></st1placetype></st1place><span style="font-family: "MS Mincho";"> of
Medicine<span>  </span><op></op></span></p>
<p class="MsoNormal"><span style="font-family: "MS Mincho";">3<span>  </span></span><st1city><st1place><span style="font-family: "MS Mincho";">Nagasaki</span></st1place></st1city><span style="font-family: "MS Mincho";"> Thoracic
Oncology Group <op></op></span></p>
<p class="MsoNormal"><span style="font-family: "MS Mincho";">4<span>  </span></span><st1place><st1placename><span style="font-family: "MS Mincho";">Kawasaki</span></st1placename><span style="font-family: "MS Mincho";">
</span><st1placename><span style="font-family: "MS Mincho";">Medical</span></st1placename><span style="font-family: "MS Mincho";">
</span><st1placetype><span style="font-family: "MS Mincho";">School</span></st1placetype></st1place><span style="font-family: "MS Mincho";"><span>  </span><op></op></span></p>
<p class="MsoNormal"><span style="font-family: "MS Mincho";">Background: Gefitinib is a selective EGFR tyrosine kinase
inhibitor, and has the anti-tumor activity for lung<span>  </span>cancer. Recently, there are a few reports
about the efficacy of re-treatment with gefitinib in lung cancer<span>  </span>patients. Methods: We retrospectively analyzed
patients with advanced lung adenocarcinoma, who received re-<span>  </span>treatment with gefitinib in NTOG hospitals.
We informed patients about predictive effects and adverse events<span>  </span>of this re-treatment. Results: A total of
eight patients with stage IV disease were analyzed. The patients<span>  </span>characteristics were as follows; median age
(range) = 63 (49-80), male/female = 2/6, PS0/1/2/3/4 = 0/4/1/2/1,<span>  </span>smoker/non-smoker = 2/6. First line gefitinib
treatment showed the effectiveness in seven and no response in<span>  </span>another one. The reasons of discontinue of
first line gefitinib therapy were liver dysfunction in two and tumor<span>  </span>progression in another six. Re-treatment with
gefitinib showed the efficacy in six and disease progression in<span>  </span>two. In six responders by re-treatment, five
patients had tumor progression after the first line therapy. These<span>  </span>five patients were male/female = 1/4,
smoker/non-smoker = 1/4. Mild tumor reduction and improve of<span>  </span>symptom were achieved in three and decrease
of CEA levels in two of these five patients. Conclusions: Re-<span>  </span>treatment with gefitinib may have the
efficacy to selected patients with gefitinib resistant lung<span>  </span>adenocarcinoma<op></op></span></p>
<p class="MsoNormal"><span style="font-family: "MS Mincho";"><op> </op></span></p>
<p class="MsoNormal"><span style="font-family: "MS Mincho";">重</span>
<span style="font-family: "MS Mincho";">新使用</span>iressa<span style="font-family: "MS Mincho";">治</span><span style="font-family: PMingLiU;">疗晚期肺腺癌患者的回顾分析</span>:</p>
<p class="MsoNormal"><span style="font-family: "MS Mincho";">Takashi Kasai<span>  </span>1<span>  </span>, Hiroshi Soda<span>  </span>2<span>  </span>,
Hiroshi Takatani<span>  </span>3<span>  </span>, Minoru Fukuda<span>  </span>4<span>  </span>,
Reiji Nakano<span>  </span>3<span>  </span>,<span> 
</span>Akitoshi Kinoshita<span>  </span>3<span>  </span>, Masaaki Fukuda<span>  </span>3<span>  </span>,
Seiji Nagashima<span>  </span>3<span>  </span>, Yoichi Nakamura<span>  </span>2<span>  </span>,
Yoshifumi Soejima<span>  </span>3<span>  </span>,<span> 
</span>Mikio Oka<span>  </span>4<span>  </span>, Shigeru Kohno<span>  </span>2<span>  </span><op></op></span></p>
<p class="MsoNormal">1<span style="font-family: PMingLiU;">谏早总医院</span>, <span style="font-family: PMingLiU;">长崎</span>,<span style="font-family: "MS Mincho";"> 日本</span><span style="font-family: PMingLiU;"><op></op></span></p>
<p class="MsoNormal">2<span style="font-family: "MS Mincho";">日本</span><span style="font-family: PMingLiU;">长崎大学医学院,长崎胸部肿瘤组<op></op></span></p>
<p class="MsoNormal">4<span style="font-family: PMingLiU;">长</span><span style="font-family: "MS Mincho";">崎医学院<op></op></span></p>
<p class="MsoNormal"><span style="font-family: "MS Mincho";">背景<op></op></span></p>
<p class="MsoNormal">iressa<span style="font-family: "MS Mincho";">是一</span><span style="font-family: PMingLiU;">种选择性</span>EGFR<span style="font-family: "MS Mincho";">酪氨酸激</span><span style="font-family: Batang;">酶抑制</span><span style="font-family: PMingLiU;">剂</span>,<span style="font-family: "MS Mincho";">并具有抗</span><span style="font-family: PMingLiU;">肿瘤活性</span>,<span style="font-family: PMingLiU;">为肺癌</span>. <span style="font-family: "MS Mincho";">最近</span>,<span style="font-family: "MS Mincho";">有一些</span><span style="font-family: PMingLiU;">报道了</span><span style="font-family: "MS Mincho";">重</span>
<span style="font-family: "MS Mincho";">新使用</span>iressa<span style="font-family: "MS Mincho";"></span><span style="font-family: "MS Mincho";">治</span><span style="font-family: PMingLiU;">疗肺癌患者疗效</span>.</p>
<p class="MsoNormal"><span> </span><span style="font-family: "MS Mincho";">方法</span>:</p>
<p class="MsoNormal"><span style="font-family: "MS Mincho";">回</span><span style="font-family: PMingLiU;">顾分析,</span>12<span style="font-family: "MS Mincho";">例中</span><span style="font-family: PMingLiU;">晚期肺腺癌</span>,<span style="font-family: "MS Mincho";">他</span><span style="font-family: PMingLiU;">们接到</span><span style="font-family: "MS Mincho";">重</span>
<span style="font-family: "MS Mincho";">新使用</span>iressa<span style="font-family: "MS Mincho";"></span><span style="font-family: "MS Mincho";">的治</span><span style="font-family: PMingLiU;">疗,在NTOG</span><span style="font-size: 10pt;">
</span><span style="font-family: "MS Mincho";">医院</span>. <span style="font-family: "MS Mincho";">我</span><span style="font-family: PMingLiU;">们告诉病人</span><span style="font-family: "MS Mincho";">重</span>
<span style="font-family: "MS Mincho";">新使用iressa的</span><span style="font-family: PMingLiU;">预测疗效和不良后果</span>. <span style="font-family: PMingLiU;">结果</span>:</p>
<p class="MsoNormal"><span style="font-family: "MS Mincho";">一共有八个第四期患者</span><span style="font-family: PMingLiU;">进行了分析</span>. <span style="font-family: "MS Mincho";">病人的特点如下</span>; <span style="font-family: "MS Mincho";">年</span><span style="font-family: PMingLiU;">龄中位数</span>(<span style="font-family: "MS Mincho";">范</span><span style="font-family: PMingLiU;">围</span>) = 63 ( 1949<span style="font-family: "MS Mincho";">年至</span>1980<span style="font-family: "MS Mincho";">年</span>) ,<span style="font-family: "MS Mincho";">男</span>/<span style="font-family: "MS Mincho";">女</span>= 2 / 6 , <span style="font-family: "MS Mincho";">S</span> 0/1/2/3/4 = 0/4/1/2/1 , <span style="font-family: "MS Mincho";">抽烟</span>/<span style="font-family: "MS Mincho";">不抽烟</span>= 2 / 6 . <span style="font-family: "MS Mincho";">第一</span><span style="font-family: PMingLiU;">线治疗显示七患者</span><span style="font-family: "MS Mincho";">有</span><span style="font-family: PMingLiU;">效果</span>, ,<span style="font-family: "MS Mincho";">在另一</span><span style="font-family: PMingLiU;">患者</span><span style="font-family: "MS Mincho";">没有反</span><span style="font-family: PMingLiU;">应</span>.</p>
<p class="MsoNormal"><span style="font-family: "MS Mincho";">停止一</span><span style="font-family: PMingLiU;">线治疗</span><span style="font-family: "MS Mincho";">原因,两人</span><span style="font-family: PMingLiU;">肝功能不正常</span>,<span style="font-family: PMingLiU;">另外</span>6<span style="font-family: "MS Mincho";">人</span><span style="font-family: PMingLiU;">癌进展</span>. <span style="font-family: "MS Mincho";">重新使用IRESSA在六个病人</span><span style="font-family: PMingLiU;">显</span><span style="font-family: "MS Mincho";">示效果,</span><span style="font-family: PMingLiU;">另外两</span><span style="font-family: "MS Mincho";">人</span><span style="font-family: PMingLiU;">癌进展</span>. <span style="font-family: "MS Mincho";">在六个有反</span><span style="font-family: MingLiU;">应的</span><span style="font-family: "MS Mincho";">病人中</span>, <span style="font-family: "MS Mincho";">其中</span>5<span style="font-family: "MS Mincho";">例是</span><span style="font-family: PMingLiU;">第一线治疗肿瘤有效后又进展的</span>. <span style="font-family: PMingLiU;">这</span>5<span style="font-family: "MS Mincho";">例中</span>,<span style="font-family: "MS Mincho";">男</span>/<span style="font-family: "MS Mincho";">女</span>= 1 / 4 ,<span style="font-family: "MS Mincho";">抽烟</span>/<span style="font-family: "MS Mincho";">不抽烟</span>= 1 / 4, 5<span style="font-family: "MS Mincho";">人中,</span><span style="font-family: PMingLiU;">三个取得了</span>
<span style="font-family: PMingLiU;">轻度肿瘤减小和改善症状,</span>
<span style="font-family: "MS Mincho";">两艘</span>CEA<span style="font-family: "MS Mincho";">水平</span><span style="font-family: PMingLiU;">下降。<op></op></span></p>
<p class="MsoNormal"><span style="font-family: PMingLiU;">结论<op></op></span></p>
<span style="font-size: 12pt; font-family: PMingLiU;">对选定的对IRESSA抗药的肺腺癌患者,</span><span style="font-size: 12pt; font-family: "MS Mincho";">重</span><span style="font-size: 12pt; font-family: "Times New Roman";">
</span><span style="font-size: 12pt; font-family: "MS Mincho";">新使用</span><span style="font-size: 12pt; font-family: "Times New Roman";">Gefitinib</span><span style="font-size: 12pt; font-family: PMingLiU;">可以有</span> |
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