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发表于 2007-8-1 20:51:15
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来自: 中国辽宁大连
<span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">肺部药物剂量的每周沉积量的计算结果分别为以前给接受过氨基钾酸脂的白鼠进行治疗而未能发生作用的口服剂量的</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">0.01</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">﹪</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">,0.07</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">﹪和</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">1.1</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">﹪</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">.10</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">~</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">16</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">周以后</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">,</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">解剖白鼠</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">,</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">统计肺部增生和肿瘤的数量</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">.</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">对于所有的致癌物质</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">,</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">接受高剂量异维甲酸的白鼠</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">,</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">肿瘤的多样性出现了</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">56</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">﹪~</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">80</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">﹪</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">(P</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;"><</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">0.005)</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">的降低</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">;</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">接受中等剂量异维甲酸的白鼠</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">,</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">肿瘤的多样性出现了</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">67</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">﹪~</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">88</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">﹪</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">(P</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;"><</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">0.005)</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">的降低</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">;</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">接受小剂量治疗的经过</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">BaP</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">和</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">NNK</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">处理的白鼠</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">,</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">多样化的降低程度分别为</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">30</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">﹪</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">(P</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;"><</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">0.13)</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">和</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">16</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">﹪</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;"> (P</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;"><</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">0.30),</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">差异无显著性</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">.</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">在接受</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">BaP</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">和</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">NNK</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">的白鼠中</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">,</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">增生区域的数量与剂量呈正相关</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">,</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">而与肿瘤数量成反比</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">,</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">表明有抑制作用</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">.</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">相对于接受乙醇吸入的白鼠</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">,</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">吸入中等剂量异维甲酸可以引起肺组织的维甲酸受体</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">(RAR)</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">的变化</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">,</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">具体表现为</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">RARα(3.9</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">倍于乙醇组</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">)</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">、</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">RARβ(3.3</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">倍</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">)</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">和</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">RARγ(3.7</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">倍</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">).</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">结论维甲酸受体是该系统内的类维生素</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">A</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">活性的有效生物标志</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">,</span><span style="COLOR: #666666; FONT-FAMILY: 宋体; mso-ascii-font-family: Tahoma; mso-hansi-font-family: Tahoma; mso-font-kerning: 0pt; mso-bidi-font-family: Tahoma;">吸入异维甲酸有利于有肺癌高发危险的人群预防肺癌</span><span lang="EN-US" style="COLOR: #666666; FONT-FAMILY: Tahoma; mso-font-kerning: 0pt;">.</span> |
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