妈妈中分化肺腺3期B手术后六年8个月（2012年6月6日凌晨驾鹤西去）

我是小猫

原帖由 amei 于 2009-2-27 07:58 发表
小猫：
    我有点想让我妈妈吃5停2了，不知是否可行，你能给点意见么

我觉得问题应该不大。你可以先给你母亲试吃，如果觉得不太好，停掉会马上恢复的。

我是小猫

原帖由 xiaosay 于 2009-2-27 13:20 发表
小猫：你好!看到你的帖子非常的感动。真想和你成为朋友。
我的妈妈2004年6月查出肺腺癌，左肺叶做了切除术，并开始用紫杉醇+顺铂做了6期化疗，可是2007起开始脑转移，骨转移，做了全脑放疗加伽马刀，2008年2月开始服 ...

谢谢您，非常感谢您的鼓励。我认为西乐葆在我母亲身上有用，但是有很多人试过也无效。所以药品因人而宜。需要试。你还是要提前带你母亲去做一个全面的检查，从血，CT， 骨扫等来断定易瑞沙是否耐药。西乐葆本身也有止疼的作用。我母亲现在仍未确诊骨转，她自己也不疼，但是我让我妈妈一个月打一次博宁。骨痛止痛药物很多，只有疼痛难忍时才用吗啡类药物。所以我想如果你母亲心脏没有太大问题，可以试验易瑞沙+西乐葆。

xiaosay

谢谢，希望以后多沟通，我也是北京的。祝一切好！

我是小猫

试试蒂清加反映停吧，这是文献

Cancer. 2005 Jun 15;103:2590-7 15861414  [Cited: 1]     

Temozolomide plus thalidomide in patients with brain metastases from melanoma: a phase II study.
蒂清加反映停治疗来自黑色素癌的脑转移瘤的二期研究
   
Wen-Jen Hwu , Eric Lis , Jennifer H Menell , Katherine S Panageas , Lynne A Lamb , Janene Merrell , Linda J Williams , Susan E Krown , Paul B Chapman , Philip O Livingston , Jedd D Wolchok , Alan N Houghton
BACKGROUND: Temozolomide plus thalidomide is a promising oral combination regimen for the treatment of metastatic melanoma. The current Phase II study examined the efficacy and safety of this combination in chemotherapy-naive patients with brain metastases. METHODS: Patients with histologically confirmed metastatic melanoma and measurable brain metastases received temozolomide (75 mg/m2 per day for 6 weeks with a 2-week break between cycles) plus concomitant thalidomide (200 mg/day escalating to 400 mg/day for patients < 70 years or 100 mg/day escalating to 250 mg/day for patients > or = 70 years). The primary end point was tumor response in the brain assessed every 8 weeks.患者经病理证实的转移性黑素瘤和可衡量的脑转移瘤，收到了蒂清（ 75MG，每天2次，6周，然后休息2周） ，另加伴（反映停
200毫克/天逐步升级至400毫克/天，--对患者< 70岁，或100毫克/天逐步升级至250毫克/天，--对患者>= 70岁）
。主要终点是肿瘤在大脑中反应，每8周评估一次)(RESULTS: Twenty-six patients with a median age of 60 years were treated. All patients had progressive brain metastases: 16 were symptomatic and 25 had extensive extracranial metastases. Eight patients had received whole-brain radiotherapy, 4 had received stereotactic radiotherapy, and 8 had received craniotomy with resection of hemorrhagic lesions. Fifteen patients completed > or = 1 cycle (median, 1 cycle; range, 0-4 cycles), and 11 discontinued treatment before completing 1 cycle (7 for intracranial hemorrhage, 2 for pulmonary embolism, 1 for deep vein thrombosis, and 1 for Grade 3 rash). Of 15 patients assessable for response, 3 had a complete or partial response (12% intent to treat) and 7 had minor response or stable disease in the brain. However, 5 of these 10 patients had disease progression at extracranial sites. The median survival period was 5 months for all 26 patients and 6 months for the 15 assessable patients. CONCLUSIONS: Temozolomide plus thalidomide was an active oral regimen for patients with brain metastases from malignant melanoma.
Mesh-terms: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols, therapeutic use; Brain Neoplasms, drug therapy; Brain Neoplasms, secondary; Dacarbazine, administration & dosage; Dacarbazine, analogs & derivatives; Disease-Free Survival; Female; Humans; Male; Melanoma, drug therapy; Melanoma, secondary; Middle Aged; Neoplasm Staging; Research Support, Non-U.S. Gov't; Skin Neoplasms, drug therapy; Skin Neoplasms, pathology; Survival Rate; Thalidomide, administration & dosage; Treatment Outcome;

我是小猫

北京最近天气很好，妈妈出门锻炼的时间也早了些，虽然没有易的治疗，从病人的感觉和锻炼的情况来看， 妈妈和以前没有什么差别。除睡眠和大便不太正常外，食欲很好，精神也还可以。快到一个月了，希望有个好的检查结果。

weiwuzi

鼓励一下！
祝福，期待！

amei

小猫，你妈妈用西乐葆有嗜睡的感觉么？我妈每次休息之后再次重新使用的时候开始会在早上睡一觉，也不是很有精神，不知是不是西乐葆引起了嗜睡的副作用呢

sissi_lee1107

谢谢你的回答，小猫！