讨论，有没有可以预防脑转移的方法？

shirley8033

据说腺癌90%都会脑转移，最近也看到好多论坛里面的病友，易瑞沙耐药后首先发现的就是脑转移。。

所以在想，有没有什么方法，偏方是可以预防脑转移的呢？

有知道的都说一下吧。。

LIAO333提供的，北京老中医说的，青蒿+薏仁  各30克，坚持每天煲水喝。。不知道有没有用呢？

DCA？DCA进入人体内后有25%是进入脑部，其它的经过人体的肾脏新阵代谢掉，如果DCA有效，那么，是否也可以作为预防脑转移的用药呢？？

大家一起讨论一下吧。。

javier

这也是我很担心的问题

有报告PCI有助于降低脑转几率，但无益生存率．医生也说NSCLC不要做PCI

转一个帖子：

肺腺癌多发脑转移患者－服用dca－近期感觉头脑较清晰

我父现年66岁。2007年5月下旬发现肺腺癌多发脑转移。现同服易瑞沙、dca。
易瑞沙服用4个月，期间经两次磁共振显示：头部病灶均有缩小，水肿已消失大部分；
dca服用21天，用量从5mg/kg/d开始－现在10mg/kg/d，分两次饭后服用。据病人自己称近期感觉头脑较清晰、思维较敏捷。
服用易瑞沙副作用较大：全身及头面部湿疹、皮肤骚痒、腹泻、脱皮、肝功能异常、脱发、食欲影响。
服用dca暂时未发现明显副作用。
目前服用的dca辅剂：谷胱甘肽250mg/d、硫辛酸200mg/d、辅酶（q10)30mg/d、VC300mg/d、VE300mg/d、VB1 60mg/d、绿藻片6g/d。

我又问了我父亲，他说他觉得明显是服用不久的dca产生的效果，并且脚下也实在了许多，不发虚了，这在服用dca之前是没有的。他现在晚上敢独自去较远的地方散步锻炼了。

dca辅剂做起来有点麻烦，关注中．．．

jimmy112199

有，文献介绍，NSCLC患者，将原发病灶控制在3。9厘米以下，可以有效的防止脑转，原文为英文。

之之

QUOTE:

以下是引用jimmy112199在2007-11-21 7:35:08的发言：
有，文献介绍，NSCLC患者，将原发病灶控制在3。9厘米以下，可以有效的防止脑转，原文为英文。

文献介绍在哪呢?事实上有很多小病灶大转移的例子,通过血液传播的.

癌细胞就是往营养丰富供血足的器官转移,如果这个器官以前受过什么损伤,正好是薄弱环节抵御力低,就被有机可乘了.

jimmy112199

QUOTE:

以下是引用之之在2007-11-22 23:49:27的发言：

文献介绍在哪呢?事实上有很多小病灶大转移的例子,通过血液传播的.

癌细胞就是往营养丰富供血足的器官转移,如果这个器官以前受过什么损伤,正好是薄弱环节抵御力低,就被有机可乘了.

Lung Cancer Evaluation and Diagnosis

Wednesday, November 2, 2005

12:30 PM - 2:00 PM

CORRELATION BETWEEN LUNG MASS SIZE IN NON-SMALL CELL LUNG CANCER (NSCLC) AND BRAIN METASTASES

H. Aziz, MD, A. Blamoun, MD, M. Shubair, MD, M.M. Ismail, MD* and M.A. Khan, MD

St. Joseph’s Regional Medical Center, Paterson, NJ

PURPOSE: The aim of our study was to determine whether the size of a primary NSCLC predicts the presence of brain metastases.

METHODS: We retrospectively reviewed the size of lung mass by CT scan of the chest in 35 patients (16 males, 19 females, age range 41-95 yrs; mean age 67.4yrs) who were diagnosed with NSCLC during the past two years whose CT scans of the brain were negative for brain metastases. We then compared it with the size of the lung mass in CT scan of the chest in 35 patients (16 males, 19 females, age range 41-91 yrs; mean age 65.7 Yrs) who were also diagnosed with NSCLC but had CT scans of the brain that showed brain metastases.

RESULTS: The size of lung mass in patients without brain metastases was smaller (mean 3.311±1.668cm; 95%CI= 2.738-3.884) than in those with brain metastases (mean 4.866±2.612cm; 95%CI=3.969-5.763). At a cut-off of 3.9cm (determined by ROC curve analysis), the odds ratio of brain metastases was 13.96 (P<0.0001).

CONCLUSION: There is direct correlation between the size of the lung mass and brain metastases in NSCLC.

CLINICAL IMPLICATIONS: Lung mass size 3.9cm in NSCLC predicts the presence of brain metastases.

Lung Mass Size (cm) Metastases No Metastases 3.9 26 6 <3.9 9 29

DISCLOSURE: M.M. Ismail, None.

shirley8033

哪位可以翻译一下。。看不懂。

jimmy112199

非小细胞肺癌（ NSCLC ）肺部肿块大小和脑转移的相关联性

医学博士阿齐兹，

圣若瑟的区域医疗中心，百德，新泽西

肺癌的评价与诊断

周三， 2005年11月2日

下午12:30 -下午2 :00

目的：本研究的目的是要确定是否非小细胞肺癌原发肿瘤的大小可预测脑转移的存在。

方法：我们回顾性的重新查看了，在过去的两年中，35例（男16 ，女19例，年龄41-95岁，

平均年龄67.4yrs）经胸部CT扫描被诊断为晚期非小细胞肺癌，而他们的脑部CT扫描均呈阴性反应的病人的肺部肿块的大小。然后，我们比较了35例（男16 ，女19例，年龄41-91岁，平均年龄65.7岁) ，在胸部CT扫描，也确诊为肺癌，但CT扫描大脑中显示脑转移的病人肺部肿块的大小。

结果：患者无脑转移的肺部肿块较小（平均为3.311 ± 1.668厘米;百分之九十五信赖区间为2.738-3.884 ），比那些脑转移（平均4.866 ± 2.612厘米;百分之九十五信赖区间为3.969-5.763 ）。分界点是3.9厘米（取决于ROC曲线分析） ，脑转移瘤的概率比是13.96（ P < 0.0001 ） 。

结论：非小细胞肺癌脑转移瘤与肺部肿块大小有直接关联。

临床意义：非小细胞肺癌肺部肿块>=3.9厘米预测脑转移瘤的存在。

肺部肿块大小（厘米）的转移不转移

肺部肿块大小（厘米） 转移 不转移 3.9 26 6 <3.9 9 29

DISCLOSURE: M.M. Ismail, None.

 

 

Lung Cancer Evaluation and Diagnosis

Wednesday, November 2, 2005

12:30 PM - 2:00 PM

CORRELATION BETWEEN LUNG MASS SIZE IN NON-SMALL CELL LUNG CANCER (NSCLC) AND BRAIN METASTASES

H. Aziz, MD, A. Blamoun, MD, M. Shubair, MD, M.M. Ismail, MD* and M.A. Khan, MD

St. Joseph’s Regional Medical Center, Paterson, NJ

PURPOSE: The aim of our study was to determine whether the size of a primary NSCLC predicts the presence of brain metastases.

METHODS: We retrospectively reviewed the size of lung mass by CT scan of the chest in 35 patients (16 males, 19 females, age range 41-95 yrs; mean age 67.4yrs) who were diagnosed with NSCLC during the past two years whose CT scans of the brain were negative for brain metastases. We then compared it with the size of the lung mass in CT scan of the chest in 35 patients (16 males, 19 females, age range 41-91 yrs; mean age 65.7 Yrs) who were also diagnosed with NSCLC but had CT scans of the brain that showed brain metastases.

RESULTS: The size of lung mass in patients without brain metastases was smaller (mean 3.311±1.668cm; 95%CI= 2.738-3.884) than in those with brain metastases (mean 4.866±2.612cm; 95%CI=3.969-5.763). At a cut-off of 3.9cm (determined by ROC curve analysis), the odds ratio of brain metastases was 13.96 (P<0.0001).

CONCLUSION: There is direct correlation between the size of the lung mass and brain metastases in NSCLC.

CLINICAL IMPLICATIONS: Lung mass size 3.9cm in NSCLC predicts the presence of brain metastases.

Lung Mass Size (cm) Metastases No Metastases 3.9 26 6 <3.9 9 29

DISCLOSURE: M.M. Ismail, None.