溃疡药可治肺癌（老药新用）

LQQ

http://med.stanford.edu/profiles ... 4&fid=6603&

说的是下面这篇文章吗，如果是这个教授，到是可以发去问问

Atul Butte
Academic Appointments Associate Professor, Pediatrics - Systems Medicine
Member, Bio-X
Member, Cancer Center
Associate Professor (By courtesy), Computer Science
Associate Professor (By courtesy), Medicine - Immunology & Rheumatology


Publication DetailsComputational repositioning of the anticonvulsant topiramate for inflammatory bowel disease.
Dudley JT, Sirota M, Shenoy M, Pai RK, Roedder S, Chiang AP, Morgan AA, Sarwal MM, Pasricha PJ, Butte AJ. Sci Transl Med. 2011; 3 (96): 96ra76

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract for which there are few safe and effective therapeutic options for long-term treatment and disease maintenance. Here, we applied a computational approach to discover new drug therapies for IBD in silico, using publicly available molecular data reporting gene expression in IBD samples and 164 small-molecule drug compounds. Among the top compounds predicted to be therapeutic for IBD by our approach were prednisolone, a corticosteroid used to treat IBD, and topiramate, an anticonvulsant drug not previously described to have efficacy for IBD or any related disorders of inflammation or the gastrointestinal tract. Using a trinitrobenzenesulfonic acid (TNBS)-induced rodent model of IBD, we experimentally validated our topiramate prediction in vivo. Oral administration of topiramate significantly reduced gross pathological signs and microscopic damage in primary affected colon tissue in the TNBS-induced rodent model of IBD. These findings suggest that topiramate might serve as a therapeutic option for IBD in humans and support the use of public molecular data and computational approaches to discover new therapeutic options for disease.

PubMedID: 21849664

奇迹的起点

还有下文吗？人为什么热衷于投巨资于武器和杀戮，却不愿为身边的、甚至自己将来就可能遇到的病痛多投入一些精力？