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发表于 2008-11-10 05:22:35
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来自: 英国
heping,你好!
我在网上查到即使作为Wilson's disease的药物,Tetrathiomolybdate也还只是在临床试验阶段而已。但是有其它几种已经在使用的去除体内铜的药物,不知道有没有和TM一样的机理可以控制癌的生长呢?其中Trientine可同时作用于铜和铁
The goal of Wilson's disease treatment is twofold:
* To remove excess copper
* To prevent copper from building up again
Once treatment starts, the disease stops progressing and many signs and symptoms improve. But some problems may take time to resolve. Other problems — especially liver scarring and certain neurological or psychological symptoms — may not be completely reversible. Untreated Wilson's disease is always fatal.
Doctors usually prescribe one of the following medications to help treat Wilson's disease:
* Penicillamine (Cuprimine, Depen). Chelation therapy is the use of chemicals to bind to and remove metals and minerals. Penicillamine was the first copper chelating drug approved for use in Wilson's disease. It works by binding to copper and creating a water-soluble complex that's excreted in your urine. Although it's an effective treatment, penicillamine can cause serious side effects, including skin problems, bone marrow suppression, worsening of neurological symptoms and birth defects.
Penicillamine shouldn't be taken by people with kidney disease or those who are allergic to penicillin. If you do chose to be treated with the drug, you'll also need to take vitamin B-6 supplements because penicillamine can cause a serious deficiency of this vitamin.
* Trientine (Syprine). Another chelating agent, trientine also binds to copper and helps eliminate it from your body. Because it's less toxic than penicillamine, many doctors consider it a first-line therapy, especially in people with liver or neurological symptoms. Trientine also binds to iron, and taking iron supplements can reduce the drug's effectiveness.
*Zinc acetate. Working differently from chelating drugs, the mineral zinc helps prevent copper from being absorbed in your stomach and small intestine. Zinc has few side effects, but it's slower acting than are penicillamine and trientine and so is usually considered an initial treatment only for pregnant women, for people without symptoms or liver damage, or for those who can't tolerate stronger medications.
Doctors may switch people taking penicillamine or trientine to zinc once their symptoms improve, or zinc may be used in combination with penicillamine for people with neurological symptoms.
* Tetrathiomolybdate. This copper-binding agent is being studied in clinical trials. |
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