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转载: 安宫牛黄丸治疗晚期肺癌痰热壅肺证26例

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发表于 2008-4-10 16:05:57 | 显示全部楼层 |阅读模式 来自: 中国河北石家庄
<p class="MsoNormal" align="left" style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center;"><b style="mso-bidi-font-weight: normal;"><u style="text-underline: dash-dot-heavy;"><span style="FONT-SIZE: 14pt; COLOR: gray; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.0pt; mso-color-alt: #993300; text-effect: emboss;"><font size="2">原文: 同仁堂网站--http://www.tongrentang.com/trtyg/agnh/12.doc</font></span></u></b></p><p class="MsoNormal" align="center" style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center;"><b style="mso-bidi-font-weight: normal;"><u style="text-underline: dash-dot-heavy;"><span style="FONT-SIZE: 14pt; COLOR: gray; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.0pt; mso-color-alt: #993300; text-effect: emboss;"></span></u></b></p><p class="MsoNormal" align="center" style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center;"><b style="mso-bidi-font-weight: normal;"><u style="text-underline: dash-dot-heavy;"><span style="FONT-SIZE: 14pt; COLOR: gray; FONT-FAMILY: 宋体; mso-bidi-font-size: 10.0pt; mso-color-alt: #993300; text-effect: emboss;">安宫牛黄丸治疗晚期肺癌痰热壅肺证<span lang="EN-US">26例</span></span></u></b><b><span lang="EN-US" style="FONT-SIZE: 14pt; FONT-FAMILY: 宋体; mso-bidi-font-family: 宋体;"><p></p></span></b></p><p class="MsoNormal" align="center" style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center;"><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-weight: bold; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;">&nbsp;<p></p></span></p><p class="MsoNormal" align="center" style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center;"><span style="FONT-FAMILY: 宋体; mso-bidi-font-weight: bold; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;">□ 丁庆生</span><span style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;">
                        <span style="mso-bidi-font-weight: bold;">(广东省广州市黄埔区中医院<span lang="EN-US"> 510700)</span></span><span lang="EN-US"><p></p></span></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;"><span style="mso-spacerun: yes;">&nbsp; </span><p></p></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 21.1pt; mso-char-indent-count: 2.0; mso-char-indent-size: 10.55pt;"><b><span style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;">关键词</span></b><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;"><span style="mso-spacerun: yes;">&nbsp; </span>安宫牛黄丸;晚期肺癌;痰热壅肺证<p></p></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 21.1pt; mso-char-indent-count: 2.0; mso-char-indent-size: 10.55pt;"><b><span style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;">中图法分类号</span></b><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;"><span style="mso-spacerun: yes;">&nbsp; </span>R734.2<p></p></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;"><span style="mso-spacerun: yes;">&nbsp;&nbsp;&nbsp; </span><p></p></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 21pt; mso-char-indent-count: 2.0; mso-char-indent-size: 10.5pt;"><span style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;">笔者自<span lang="EN-US">1987年以来,运用安宫牛黄丸治疗晚期肺癌痰热壅肺证26例,临床取得一定效果,现报道如下。<p></p></span></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 21pt; mso-char-indent-count: 2.0; mso-char-indent-size: 10.5pt;"><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;">&nbsp;<p></p></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 21.1pt; mso-char-indent-count: 2.0; mso-char-indent-size: 10.55pt;"><b><u><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;">1 临床资料<p></p></span></u></b></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;"><span style="mso-spacerun: yes;">&nbsp;&nbsp;&nbsp; </span>26例晚期肺癌中,男21例,女5例,年龄46~76岁,平均59岁。<p></p></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;"><span style="mso-spacerun: yes;">&nbsp;&nbsp;&nbsp; </span>均经病理学诊断和X线检查证实。鳞状上皮癌18例,未分化癌2例,腺癌6例。其中伴有肺外转移23例,经手术治疗后16例,伴胸腔积液22例。<p></p></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;"><span style="mso-spacerun: yes;">&nbsp;&nbsp;&nbsp; </span>痰热壅肺证主要表现为咳喘加剧,呼吸急促,喉中痰鸣,或神识昏蒙,舌紫红,苔黄腻而干,脉弦滑或滑数。<p></p></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 21.1pt; mso-char-indent-count: 2.0; mso-char-indent-size: 10.55pt;"><b><u><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;">2 治疗方法<p></p></span></u></b></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;"><span style="mso-spacerun: yes;">&nbsp;&nbsp;&nbsp; </span>安宫牛黄丸1/3粒,化水口服。痰涎排出后,可用益气养阴健脾之品善后。<p></p></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;"><span style="mso-spacerun: yes;">&nbsp;&nbsp;&nbsp; </span>药丸剂量宁少毋多,可少少频服,根据病人的体质强弱而定,宜中病即止,以防耗伤正气。<p></p></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 21.1pt; mso-char-indent-count: 2.0; mso-char-indent-size: 10.55pt;"><b><u><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;">3 疗效观察<p></p></span></u></b></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;"><span style="mso-spacerun: yes;">&nbsp;&nbsp;&nbsp; </span>26例经治疗,显效(有大量痰涎排出,呼吸急促症状消失,神识清楚)23例,好转(呼吸基本平稳,神识转清,喘咳痰鸣明显减轻)3例。<p></p></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 21.1pt; mso-char-indent-count: 2.0; mso-char-indent-size: 10.55pt;"><b><u><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;">4 典型病例<p></p></span></u></b></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;"><span style="mso-spacerun: yes;">&nbsp;&nbsp;&nbsp; </span>冯某,男,52岁。患者右肺癌(鳞癌)术后2年余,因咳喘加重2周,伴见形体消瘦,动则气促,胸中窒闷,痰多黄稠,咯之不爽,于1995年10月入院。入院后予抗感染、解痉祛痰止咳,及支持疗法和中药清热化痰、泻肺平喘治疗,病情基本稳定。于11月4日受凉后,突然出现咳喘加重,呼吸急促,喉中痰鸣,咯之不出,口干口苦,恶心纳呆。舌质紫红,苔黄腻而干,脉弦滑。给予吸氧,抗感染、解痉祛痰、止咳平喘等均无效果。患者渐见神识昏蒙,时清时昧。<p></p></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;"><span style="mso-spacerun: yes;">&nbsp;&nbsp;&nbsp; </span>予安宫牛黄丸1/3粒化水,频频口服。服后约1h,患者咳出黄白相兼之痰涎盈盂,咳喘症状明显缓解,神识转清,继则以益气养阴健脾之品以善后,患者渐可下床轻微活动。<p></p></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;"><span style="mso-spacerun: yes;">&nbsp;&nbsp;&nbsp; </span>此后,每遇咳喘加重,痰涎壅盛,即服安宫牛黄丸,均见症状缓解。后生命延续了8个月余,终因患者全身衰竭,心肾功能亦见损害,而致死亡。<p></p></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; TEXT-INDENT: 21.1pt; mso-char-indent-count: 2.0; mso-char-indent-size: 10.55pt;"><b><u><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;">5 讨论<p></p></span></u></b></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;"><span style="mso-spacerun: yes;">&nbsp;&nbsp;&nbsp; </span>安宫牛黄丸系清代名医吴鞠通所创,由清热凉血、泻火豁痰、开窍醒神的药物组成,是用来治疗神昏闭窍之证的方剂。主治温热病,热邪内陷心包,痰热壅闭心窍所致的高热烦躁,神昏谵语,或舌謇肢厥,以及中风窍闭,小儿惊厥属痰热内闭者。然很少用于肺癌晚期所致的痰热壅肺!咳喘气促的治疗。笔者运用该丸,遵守“有是证,用是药”古训,用药指征是:①有痰热壅肺的征象,患者舌紫红,苔黄腻而干,脉弦滑或滑数;②有肺窍闭塞之象,患者呼吸急促,气道闭阻,神识昏蒙或时清时昧。<p></p></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;"><span style="mso-spacerun: yes;">&nbsp;&nbsp;&nbsp; </span>安宫牛黄丸运用于晚期肺癌痰热壅肺证,宜小剂量开始,以1/3粒化水频服,不知再服,不宜剂量过大和久服,因该丸药为芳香开窍药物,善于辛散走窜,久服则伤元气,宜中病即止。再者,肺癌晚期多见气阴两虚,更应谨慎。见效后,可用益气养阴健脾之品善后。<p></p></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;"><span style="mso-spacerun: yes;">&nbsp;&nbsp;&nbsp; </span>安宫牛黄丸方中麝香,《本草纲目》曰:“有通窍,开经络,透肌骨……治中风……痰厥,积聚症瘕。”现代研究认为麝香有抗癌作用。<p></p></span></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt;"><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;"><span style="mso-spacerun: yes;">&nbsp;&nbsp;&nbsp; </span>笔者在临床应用中发现,安宫牛黄丸除了传统的功效外,尚有改善肺通气量,促进痰涎排出的功效。<p></p></span></p><p class="MsoNormal" align="right" style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: right;"><span lang="EN-US" style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;">&nbsp;<p></p></span></p><p class="MsoNormal" style="MARGIN: 0cm 42pt 0pt 0cm; TEXT-INDENT: 21pt; mso-char-indent-count: 2.0; mso-char-indent-size: 10.5pt;"><span style="FONT-FAMILY: 宋体; mso-bidi-font-size: 10.5pt; mso-bidi-font-family: 宋体;">作者简介:丁庆生,男,<span lang="EN-US">45岁,主治医师<p></p></span></span></p><b style="mso-bidi-font-weight: normal;"><span style="FONT-SIZE: 10.5pt; FONT-FAMILY: 宋体; mso-bidi-font-family: 宋体; mso-font-kerning: 1.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA;">来源:安徽中医学院学报<span lang="EN-US"><span style="mso-spacerun: yes;">&nbsp; </span>第18卷 第2期<span style="mso-spacerun: yes;">&nbsp; </span></span></span></b>
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