CAR T cells 免疫治疗药试 - 包括肺癌

jaydad

挑刺的这样评

Juno, Kite CAR-T Stocks Fall on Disappointing Solid Tumor Data
By:Adam FeuersteinFollow | 04/20/15 - 10:22 AM EDT

Shares of Juno Therapeutics (JUNO) and Kite Pharma (KITE)are weak Monday following a lackluster showing for so-called CAR-T cellular therapies in solid tumors at a closely watched cancer conference this weekend.  

T cells taken from patients and modified by scientists at the University of Pennsylvania and Novartis (NVS) to recognize a protein found on some solid-tumor cancers could administered safely but didn't appear to have much longevity or efficacy, according to research presented Sunday at the American Association for Cancer Research (AACR) annual meeting. The new data were not altogether surprising but disappointed investors who expecting more progress for CAR-T in solid tumors. To date, all of the excitement surrounding CAR-T has come from  very high remission rates in patients with advanced blood cancers, a smaller commercial market.

Juno Therapeutics fell 6% to $60.70 in early Monday trading. Kite is down 7% to $60.79. Neither company presented data at the AACR meeting this weekend but their stocks fell because they also have solid tumor CAR-Ts in development. Ziopharm Oncology (ZIOP - Get Report)  and Bellicum Pharmaceuticals (BLCM), two more CAR-T stocks, were also trading lower Monday.

As reported Sunday, the phase I study was conducted using a CAR-T therapy from Novartis and the University of Pennsylvania. T cells were taken out of patients and modified with receptors to identify a protein known as mesothelin expressed on the surface of certain tumors. The modified T cells, now able to detect and kill mesothelin-containing tumors, were then grown and reinfused back into the patients. The new immunotherapy, known as CART-meso (short for mesothelin, 注: 间皮素, 此 CAR-T 疗法 的靶), was administered to five patients with advanced cancers no longer responding to multiple lines of prior therapy. Two patients had ovarian cancer, two had epithelial mesothelioma (a type of lung cancer) and one patient had pancreatic cancer.