英国 小细胞重大进展 4月17日
Scientists reveal lung cancer breakthroughScientists said today that they had made an important discovery in the fight against a severe form of lung cancer which affects 10,000 people in the UK each year.
Experts at the Hammersmith Hospital and Imperial College London have been analysing small cell lung cancer.
This type of lung cancer kills 97% of patients within five years of diagnosis and is difficult to treat because of the way it can resist chemotherapy.
The research team discovered that one particular molecule, a member of the PI3K (phosphoinositide 3-kinase) family, may be crucial for the spread of the disease.
The molecule influences several growth factor signals which cause cancer cells to spread and divide.
The scientists found that in small lung cancer cells, compared to normal lung tissue, there was too much of the molecule.
Professor Michael Seckl, of Hammersmith Hospital, who led the research, said: "This is an important discovery that will help us in working towards a treatment that targets and destroys the molecule and in so doing stops cancer of the lung growing."
Small cell lung cancer spreads in response to many growth factors.
This means that targeting individual growth factors is unlikely to be successful as other growth factors can simply take over.
"However identifying a common single molecule - within each cancer cell - which allows the different growth factors to work in this way is an important step forwards," Professor Seckl said.
"Small cell lung cancer kills 97% of patients within five years of diagnosis and we are desperate to identify new therapies.
"Discovering what this molecule does is a major step towards developing treatment that targets it directly and may help future generations of patients."
The study, partly funded by Cancer Research UK, is published today in the EMBO Journal, which is produced by the European Molecular Biology Organisation.
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Read more: http://www.dailymail.co.uk/health/article-140829/Scientists-reveal-lung-cancer-breakthrough.html#ixzz2z8DmtU6s
Follow us: @MailOnline on Twitter | DailyMail on Facebook 期待最直接的临床价值！ 俺们是英文盲，有中文的才好 小细胞肺癌的福音。期待！ 主要是发现了对小细胞肺癌扩散有关键作用的一个特殊的分子，它是磷脂酰肌醇(-3)激酶家族的一员，他能影响导致癌细胞增殖和扩散的促进因素，但是癌细胞有多种促进因素导致癌细胞扩散和增殖，将来就希望能找到这种分子的具体作用是朝着发明治疗的重要一步。----个人估计小细胞癌也准备研究靶向药物。
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